Marijuana has long shown promise as an effective painkiller, and that could prove to be a lifesaver – not only for patients who suffer from chronic pain but also for opiate addicts.

Dr. Daniele Piomelli, professor of anatomy and neurobiology at the University of California Irvine School of Medicine, says the use of cannabis to treat patients addicted to heroin, morphine, and other opiates could mark a turning point for addiction medicine and the people it treats – but not if the federal government stands in the way.

Federal law prohibits any use of marijuana, although 25 states allow the drug for medical use under their own statutes. That makes it harder for scientists to study the drug, which in turn has hindered efforts to fight opiate abuse.

Overdose epidemic in the United States

These lethal painkillers have sparked an overdose epidemic in the United States, with deaths from heroin and other opiates (as well as their synthetic cousins, opioids) reaching record numbers in recent years. In 2014 legal pain medications alone accounted for 19,000 deaths, more than any other prescription drugs.

Daniele Piomelli

Daniele Piomelli

Even so, it remains next to impossible for scientists to learn how useful medical marijuana might be in fighting the opiate scourge. That’s because the DEA has routinely prevented studies into the subject by blocking access to legal research cannabis.

The agency designates pot a schedule 1 narcotic alongside hard drugs such as heroin, LSD, and MDMA. These drugs are banned for any use, making it extremely hard to study them. Activists and experts like Piomelli have been pushing the DEA to reschedule pot for decades, to no avail.

Marijuana scheduling limits research

“Despite what the DEA says, their scheduling creates an enormous difficulty to researchers using marijuana or its derivatives,” says Piomelli, who has studied cannabis as a painkiller for 25 years. “Even harmless derivatives that happen to be present in the plant have been subjected to the same limitations as marijuana.”

Legislators, policymakers, and doctors have been slow to react to the explosion in opiate deaths. The healthcare system is largely responsible for the problem, as physicians and pharmaceutical companies spent years peddling prescription painkillers as healthy and non-addictive – claims that turned out to be dead wrong.

Marijuana is an effective alternative

Marijuana could help a great deal. It’s effective in relieving pain for many patients, it’s dramatically less addictive than opiates, and it has never killed anyone. CBD, a chemical found in the cannabis plant, is especially promising, Piomelli says, because it has a wide range of medical uses but doesn’t get users high.

Opiates, by contrast, are inherently intoxicating, even when used as prescribed. They are also hugely addictive, more so than any other drug but nicotine. Even legally prescribed opiates can cause full-blown addiction and ultimately death.

Will the DEA Reschedule Marijuana?

“The mu opiate receptor is so fundamental to the painkilling effects that every opiate by its very definition will cause addiction,” Piomelli says, referring to a specific group of brain cells that absorb opiate molecules.

Patients who suffer from severe pain that can’t be alleviated by other means will usually require opiates or opioids, he says, but medical marijuana could mediate the risk of addiction and overdose.

“By using a combination of the opioids and the cannabinoids, one can really lower the doses of both quite substantially,” Piomelli says. “By lowering the doses, you of course decrease the risk of addiction and the risk of side effects from both classes of compounds.”

Leave a comment and let us know: How important do you think marijuana will prove to be as a treatment for opiate addicts?

About the Author: Matt Brooks

Matt is a journalist from San Francisco who has specialized in marijuana policy for more than six years.


  1. Dan Viets September 10, 2016 at 2:23 pm - Reply

    I would like to interview Dr Piomelli about this on a radio program I host.
    If he sees this, please contact me. [email protected] Thank you.

  2. M. Layne February 27, 2018 at 12:39 am - Reply

    My comment won’t help anyone but, I need to say it……..I have exceptional Neuropathic pain in my feet because of being
    diabetic. Fortunately I have access via my Dr. to the opioid Norco. I have often thought that those that had this kind of pain
    150 years ago and had nothing to help relieve the distress….would eventually kill themselves.
    I have taken Norco for over 10 years and what I take each day needs to be cut in half…I believe Cannabis could help me do that.
    Even if I were a carded medical user here in Montana my Dr. has stated that if I am urine tested and Cannabis is found in my system I will no longer receive their help from his clinic for my pain with Norco. I am reaching a point of great desperation and worry …….Jeff Sessions may crush opiod users and make is exceptionally difficult for medical cannabis use. Even so, I think I need to have greater control over my own health and eventually move in the cannabis direction. Finally, at 65 years old, I would never admit to the use of cannabis because that would jeapordize my 2nd Amendment Rights. I will not kill myself because of the diabetic pain but….I will die to protect my 2nd Amendment Rights.

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